KPV
A tripeptide fragment of alpha-MSH, KPV is a minimal-sequence tool compound widely studied in inflammatory-signaling research. Each Vitalyx Bio vial contains 10 mg of KPV as a lyophilized powder, supplied strictly for in-vitro and laboratory research.
KPV (Lys-Pro-Val) corresponds to the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite lacking the receptor-binding motif required for melanocortin-receptor engagement, KPV retains much of alpha-MSH’s anti-inflammatory signaling capacity without its pigmentary effects — a distinction that has made it a frequently cited minimal-sequence tool for NF-κB pathway research.
Mechanism of Action
- NF-κB Inhibition: KPV suppresses nuclear translocation of NF-κB, a master regulator of inflammatory gene transcription.
- Cytokine Downregulation: Studies indicate KPV reduces pro-inflammatory cytokine secretion, including TNF-α, IL-1β, and IL-6.
- Receptor-Independent Activity: KPV lacks the sequence motif required to bind known melanocortin receptors, yet retains much of alpha-MSH’s anti-inflammatory signaling — a unique feature distinguishing it from its parent hormone.
Research Applications
- Inflammatory Bowel Disease Models: Investigated in preclinical models of IBD and ulcerative colitis for its effect on mucosal inflammation.
- Dermatological Research: Studied in models of contact dermatitis and inflammatory skin conditions for its suppression of mast-cell activation.
- Bronchial Inflammation: Explored in airway-inflammation models as an NF-κB pathway inhibitor.
Storage & Reconstitution
Keep the sealed, lyophilized vial cool, dry, and out of light, where it remains stable long-term before reconstitution. Reconstitute using sterile bacteriostatic water, directing the stream gently down the inside wall of the vial rather than onto the powder, and swirl — do not shake — until fully dissolved. Once reconstituted, store refrigerated at 2–8 °C, avoid freeze–thaw cycles, and follow your laboratory’s handling protocols.
This compound is strictly for in-vitro laboratory research use only and is not for human consumption, diagnostic, or therapeutic purposes.
References
- Melanocortin-derived tripeptide KPV has anti-inflammatory effects in murine colitis. Inflammatory Bowel Diseases, 2008. doi.org/10.1002/ibd.20334
- NF-κB related peptides: a new class of anti-inflammatory and immunomodulating drugs. Annals of the Rheumatic Diseases, 2007. doi.org/10.1136/ard.2007.079780
- The tripeptide KPV reduces intestinal inflammation in mice. Gastroenterology, 2008. doi.org/10.1053/j.gastro.2008.01.011
